Fri Aug 02 2024

23 articles - From Friday Jul 26 2024 to Friday Aug 02 2024

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

J Crohns Colitis

ECCO Crohn's Disease Guidelines-A Personal View of the Journey from Questions to Recommendations.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Association of ultra-processed food consumption with risk of microvascular complications among individuals with type 2 diabetes in the UK Biobank: a prospective cohort study.

Higher UPF consumption was associated with higher risks of diabetic microvascular complications, and the association was partly mediated through multiple potential ways.

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Childhood nutritional factors and cardiometabolic outcomes at 9-11 years of age: findings from the ROLO longitudinal birth cohort study.

Exposure to human milk in early life was associated with lower preteen adiposity, irrespective of duration. Diet quality/inflammation deteriorated between early childhood and the preteen years, highlighting a potential period for intervention.

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Consumption of Different Combinations of Human Milk Oligosaccharides in the First 6 Months of Infancy is Positively Associated with Early Cognition at 2 Years of Age in a Longitudinal Cohort of Latino Children.

This study highlights specific HMO combinations in early life influencing cognitive performance at 2 years.

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Evaluation of Daily Eating Patterns on Overall Diet Quality using Decision Tree Analyses.

Day-level eating patterns were associated with diet quality, emphasizing the relevance of both food type and timing in relation to a high-quality diet. Future interventions should investigate the potential impact of targeting food type and timing to improve diet quality.

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Metabolomics signatures of sweetened beverages and added sugar are related to anthropometric measures of adiposity in young individuals: results from a cohort study.

We identified SBs- and AS-related metabolites, which may be important for understanding the interplay between these intakes and adiposity in young individuals.

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Perceptions and Preferences for Environmentally Sustainable Food and Associated Factors: A Cross-Sectional Analysis of a Nationally Representative Survey of United States Consumers.

Associations between consumer characteristics and use of different signals for environmental sustainability were heterogeneous. Even among consumers who value environmental sustainability in food products, specific signals used by different respondents varied across demographics and health characteristics.

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Vitamin D and Heart Failure Risk among Individuals with Type 2 Diabetes: Observational and Mendelian Randomization Studies.

s/interpretation Higher serum 25(OH)D was associated with lower HF risk among individuals with T2D and the MR analysis suggested a potential causal relationship. These findings indicate a role of maintaining adequate vitamin D status in the prevention of HF among individuals with T2D.

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Inflamm Bowel Dis

Effect of Overweight and Obesity on the Response to Anti-TNF Therapy and Disease Course in Children With IBD.

Overweight/obese children with IBD were not at a higher risk of LOR to anti-TNF. Relapse in the first year after anti-TNF was introduced, but risk for relapse was increased at the end of follow-up.

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Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.

Estrogen receptor β may regulate intestinal fibrosis through modulation of the TGF-β/Smad and TLR4/MyD88/NF-κB signaling pathways. Targeting ERβ activation could be a promising therapeutic strategy for treating intestinal fibrosis.

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Long-Term Outcomes of Intravenous Ustekinumab Maintenance Treatment in Patients With Loss of Response to Subcutaneous Dosing.

No adverse events reported. IV UST maintenance effectively sustained remission in most patients at 52 weeks.

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Mucosal and Transmural Healing and Long-term Outcomes in Crohn's Disease.

Mucosal and transmural healing are associated with positive long-term outcomes for adult patients with Crohn's disease. The adoption of standardized measures and less invasive assessment tools will maximize the benefits of patient monitoring.

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J Crohns Colitis

Chronic poor sleep is associated with increased disease activity in patients with ulcerative colitis: Prospective observational study in Japan.

Concomitant chronic poor sleep may have a negative influence on the disease activity in patients with inflammatory bowel disease, especially in those with ulcerative colitis.

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Discordant effects of Janus kinases inhibition ex-vivo on inflammatory responses in colonic compared to ileal mucosa.

Site-specific anti-inflammatory effect of JAK inhibition by tofacitinib was noticed, whereby the colon was more robustly affected than the ileum. Ex-vivo response to tofacitinib is individual. JAK inhibition may attenuate inflammation by decreasing iNOS expression. Ex-vivo mucosal platforms may be a valuable resource for studying personalized drug effects in patients with IBD.

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Liver Transpl

Early living donor liver transplantation for alcohol-associated hepatitis: Status in the era of increasing demand, unmet needs, and future considerations.

The challenges of LT in living donor centers, particularly for those with AH, are unique and have previously not been discussed in depth. In this review, we aim to discuss the challenges unique to LDLT with respect to candidate and donor selection, ethical considerations, disparities in LDLT, post-LT alcohol relapse, and measures to prevent them while also addressing the definitions and outcomes of early-living donor liver LT (eLDLT) for AH.

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Impact of acute kidney injury response on survival and liver transplant rates in hospitalized patients with cirrhosis awaiting liver transplantation: Results from the HRS-HARMONY consortium.

In patients with cirrhosis waitlisted for LT who are hospitalized with AKI, AKI response to therapy is associated with improved 90-day survival, despite a reduced LT rate and longer time to LT.

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Pancreas

Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology.

Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, the identification of novel molecular targets, and the development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing three-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.

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Risk factors of acute pancreatitis in young adults: a Nationwide population-based cohort study in South Korea.

In the young adult population, alcohol consumption, smoking, hypertriglyceridemia, and obesity were associated with an elevated risk of developing AP. It is important to identify and manage the modifiable AP risk factors in young adults to minimize the socioeconomic burden of AP.

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Pancreatology

Early tumor shrinkage as a prognostic predictor in chemotherapy-naïve patients with locally advanced pancreatic cancer treated with modified FOLFIRINOX or gemcitabine plus nab-paclitaxel combination therapy: An exploratory analysis of JCOG1407.

ETS may be a prognostic predictor in chemotherapy-naïve patients with LAPC treated with mFOLFIRINOX or GnP.

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Surgical prophylaxis in pancreatoduodenectomy: Is cephalosporin still the drug of choice in patients with biliary stents in situ?

PTZ prophylaxis effectively reduced SSIs in stented patients post-pancreatoduodenectomy. Based on the local microbial profile, ceftriaxone prophylaxis may be used for prophylaxis in non-stented patients.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

J Crohns Colitis

Deciphering the Differences Between Stricturing With or Without Penetrating Crohn's Disease: One Step Closer to Solving the Puzzle.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

The Utility of Intestinal Ultrasound in a Case of Microscopic Colitis.

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Liver Transpl

Letter To The Editor:Unfair discrimination of multiple races in liver transplantation.

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Letters&Replies

Letters to the editors and authors’ replies